Na haar studie biomedische wetenschappen is Claudia Orelio gepromoveerd aan de Erasmus universiteit. Vanaf 2008 werkte ze als docent en onderzoeker moleculaire celbiologie aan het HLO, het Centrum Bioscience en Diagnostiek en het lectoraat Innovatieve Moleculaire Diagnostiek van de hogeschool Leiden.
Sinds 2015 werkt Claudia Orelio als beleidsadviseur wetenschap in het Diakonessenhuis Utrecht.
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